Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon

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Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon.

Actions of lubiprostone, a selective type-2 chloride channel activator, on mucosal secretion were investigated in guinea pig small intestine and colon. Flat-sheet preparations were mounted in Ussing flux chambers for recording short-circuit current (Isc) as a marker for electrogenic chloride secretion. Lubiprostone, applied to the small intestinal mucosa in eight concentrations ranging from 1-3...

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Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse.

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ژورنال

عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology

سال: 2009

ISSN: 0193-1857,1522-1547

DOI: 10.1152/ajpgi.90447.2008